55. Novoselov P.N.
Effect of ascorbic acid and emoxypine on the dynamics of the quantitative roentgenological and clinical semiology parameters during infiltrative tuberculosis of lungs
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Prospective, placebo-controlled randomized investigation has been performed to evaluate the effect of ascorbic acid and emoxypine on the dynamics of changes in the roentgenological and clinical pattern during infiltrative tuberculosis of lungs in comparison to the rate of Micobacterium tuberculosis eradication during the standard chemotherapy. The results show that it is expedient to include these substances in the standard chemotherapy scheme. The administration of ascorbic acid and emoxypine during the first 10 days of the standard schedule ensures accelerated resolution of tubercular infitrates and increased rate of closing of the tuberculous disintegration cavities. The use ofemoxypine accelerates the eradication of M. tuberculosis.
Экспериментальная и клиническая фармакология/”Experimental and Clinical Pharmacology”, 2009, том 72, №5, с. 22-28
56. Osikov M.V., Krivokhizhina L.V., Makarov E.V.
Influence of alpha-1-acid glycoprotein on blood rheology
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Hemorheologic effects of alpha-1-acid glycoprotein (AGP) were studied in experiment on 76 noninbred white male rats. AGP was administered i.p. to intact rats twice in a total dose of 300 mg/kg. The effects were evaluated 72 hours after the first injection. It was found that AGP accelerated platelet and erythrocyte aggregation, platelet-erythrocyte cooperation, enhanced adhesion of erythrocytes and agranulocytes to endothelium. On the contrary, adhesion of granulocytes and platelets to endothelium was diminished. Acceleration of platelet aggregation was mediated by stimulation of free radical processes in the cells. Thus, AGP produces anticoagulation action on blood theology.
Патологическая физиология и экспериментальная терапия/“Patologicheskaia Fiziologiia i Eksperimental’naia Terapiia”, 2007, №3, с. 20-21
57. Osikov M.V., Makarov E.V., Krivokhizhina L.V.
Ceruloplasmin prevents hemostatic disorders during experimental hyperammonemia
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Experimental hyperammonemia in rats was accompanied by hemostatic disorders manifesting in coagulopathy (activation of the intrinsic pathway of blood coagulation) and suppression of platelet function. Ceruloplasmin in a total dose of 60 mg/kg effectively normalized coagulation hemostasis and functional activity of platelets by improving secretory processes in platelets and increasing aggregation rate.
Бюллетень экспериментальной биологии и медицины/“Bulletin of Experimental Biology and Medicine”, 2006, том 142, №4, c. 416-418
58. Osikov M.V., Makarov E.V., Krivokhizhina L.V.
Effects of alpha1-acid glycoprotein on hemostasis in experimental septic peritonitis
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Pathogenesis of hemostasis disorders in septic peritonitis and the possibility of their correction with acute phase protein (alpha1-acid glycoprotein; two doses of 150 mg/kg) were experimentally studied on outbred albino rats. Platelets count in the peripheral blood and their adhesion to endothelium did not change during peritonitis, while aggregation activity increased due to increased rate and shorter time of aggregation, which was associated with the development of hypercoagulation involving the intrinsic and common coagulation pathways and reduction of antithrombin activity. alpha1-Acid glycoprotein increased platelet count above the normal level, normalized aggregation rate, some blood clotting parameters, and antithrombin activity. Hence, alpha1-acid glycoprotein is a polyfunctional protein modulating all pathogenetic components in the development of blood clotting disorders during septic peritonitis.
Бюллетень экспериментальной биологии и медицины/“Bulletin of Experimental Biology and Medicine”, 2007, том 144, №2, c. 178-180
