- Abramovskikh O.S., Dolgushina V.F., Telesheva L.F.
Cytokines in neoplastic processes of the cervix associated with human papillomavirus high carcinogenic risk
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Human papillomavirus high carcinogenic risk belongs to the initiating role in the development of cervical intraepithelial neoplasia and cervical cancer. Virus infection does not always cause pathology. Development of the pathology is determined by the state immunity and, primarily, local protection of the reproductive tract of women. Central role in the regulation of immune responses directed against infectious and neoplastic processes play cytokines. Objective: To study the levels of cytokines (IFN-α, IFN-γ, IL-1β, IL-2, IL-4, IL-8, IL-10, TNF-α) of cervical mucus in patients with CIN I, CIN II and CIN III, associated with human papillomavirus high carcinogenic risk. The study established significant changes of cytokine profile in neoplasia of varying severity, which have both general regularities and distinctive features associated with the progression of the pathological process of the cervix.
Российский иммунологический журнал/”Russian Journal of Immunology”, 2011, том 5(14), №1, с. 79–81
2. Abramovskikh O.S., Dolgushina V.F., Telesheva L.F., Zotova M.A., Nikushkina K.V., Mezentseva E.A.
Description of cytokine status in persistence HPV infection
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
The persistence of human papillomavirus high carcinogenic risk took place against a background of reduced immune reactivity is a major risk factor for cervical neoplasia. The levels of IL-1 β, RaIL 1, IL-2, IL-4, IL-8, IL-10, IFN γ, IFN α, TNF α has been studied in the cervical mucus of women with persistent and transient course of human papillomavirus infection. The results allow to conclude multi-directional changes in the levels of cytokines that determine the development of Th 1 immune response (decrease in the concentration of IL-2 and increased IFN γ), regardless of the persistence or elimination of HPV. At the same time, women with persistent had increase of IL-4, which determines the development of Th 2 immune response.
Российский иммунологический журнал/"Russian Journal of Immunology", 2010, том 4(13), №4, с. 428
3. Abramovskikh O.S., Telesheva L.F., Zotova M.A.
The subpopulation structure of lymphocytes of a peripheral blood at patients with cervical intraepithelial neoplasias, associated with a HPV high cancerogenic risk
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
After immunofenotypification of lymphocytes by the method of flowing cytometry at patients with CIN I, II and III degrees have been established following features: unidirectional changes of the maintenance of cells with phenotype CD3+CD4 + and CD3+19 + at the development CIN I-II; the distinctive features at CIN I - depression CD3+19- and CD3+8 + lymphocytes, at CIN III - falling CD3+HLA-DR + and CD3+16+56 + cells in peripheral blood. The progression of a cervical intraepithelial neoplasia, associated with HPV-infection is accompanied by oppression effectual and regulatory functions of T- lymphocytes, which supports pathological process and raises probability of a malignancy.
Иммунология/”Immunologiia”, 2011, №2, с. 85-87
4. Andrievskikh I.A., Fokin A.A., Grafov A.A.
Effect of immunocorrection on surgical outcomes in patients with autoimmune-aetiology vasculitis and vasculopathies
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
The present study was undertaken to investigate and compare the outcomes of three options of preoperative preparation and postoperative management of patients presenting with autoimmune-aetiology vasculitis and vasculopathies, who had been subjected to angiosurgical interventions over a 7-year period. According to the aetiopathogenetic sign, the majority of the patients appeared to have thromboangiitis obliterans, nonspecific aortoarteritis, primary and secondary vasculopathies. All the patients were age- and sex-matched and well comparable by the underlying disease, the level of lesions of the vascular bed, and the ischaemia burden. The study was performed retrospectively. A total of three options of preoperative preparation and management of the postoperative period were used: option one — treatment comprising plasmapheresis, immunoglobulins and biological immunomodulators; option two — using cytostatic agents and hormone therapy; and option three — consisting of conventional basic vascular therapy alone. The comparative analysis performed demonstrated a clear advantage ofimmuno-correction and efferent techniques of treating patients presenting with the pathology concerned. The use of the therapeutic-and-diagnostic algorithm we are suggesting herein would make it possible to avoid complications in the immediate postoperative period, to reduce the duration of the patients' hospital stay averagely by l0 days, andtoprolong persistence of the obtained positive results by 11.5%
Ангиология и сосудистая хирургия/’’Angiology and Vascular Surgery“, 2008, том 14, №2, с. 20-26
5. Barhatova N.A.
A new approach to clinical and laboratory diagnosis of generalized and local forms of soft tissue infection
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Вестник Российской академии медицинских наук/“Vestnik Rossiǐskoǐ Akademii Meditsinskikh Nauk”, 2009, №4, c. 10–13
6. Barhatova N.A.
Determination of the concentration of C-reactive protein, oligopeptides and lactoferrin of blood as a method of early diagnosis of sepsis
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Вестник хирургии им. И.И. Грекова/“Vestnik Khirurgii Imeni I.I. Grekova”, 2009, Т. 168, №4, c. 45–48
7. Barhatova N.A.
Using the conditions abacterial environment in the complex treatment of generalized forms of soft tissue infection and diabetes mellitus
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Казанский медицинский журнал/“Kazanskiǐ Meditsinskiǐ Zhurnal”, 2009, Т. 90, №1, c. 58–62
8. Barhatova N.A.
Dynamics of resistant pathogens local and generalized forms of soft tissue infection
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Казанский медицинский журнал/“Kazanskiǐ Meditsinskiǐ Zhurnal”, 2009, Т. 90, №3, c. 385–390
9. Barhatova N.A.
Use of lactoferrin of blood in the diagnosis of necrotic soft tissue infections and sepsis
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Клиническая медицина/“Klinicheskaia Meditsina”, 2008, Т. 86, №10, c. 36–39
10. Barhatova N.A.
Detoxification and anti-inflammatory therapy of generalized forms of soft tissue infection
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Хирургия. Журнал им. Н.И. Пирогова/“Khirurgia”, 2009, №5, c. 27–30
11. Belov V.V., Bordunovskii V.N., Grekova N.M., Lebedeva J.V., Tertyshnik S.S.
Effects of short-term immunosuppression on the engraftment of skin transplants at syndrome of the diabetic foot
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Effects of a single administration of small doses of 5-fluorouracil on results of skin plasty for syndrome of the diabetic foot were studied in 61 patients who had undergone local operations for pyo-necrotic diseases of the foot against the background of diabetes mellitus. The completion phase of their treatment was free dermal plasty with a split skin graft. Administration of 5-fluorouracil during the plasty operation was found to be accompanied by less marked inflammatory reaction in the transplant bed and in the graft. The frequency and square surface of lysis in the transplanted dermal skin graft were considerably lowered.
Вестник хирургии им. И.И. Грекова/”Vestnik Khirurgii Imeni I.I. Grekova”, 2007, том 166, №5, с. 32-35
12. Bordunovskii V.N., Bondarevskii I.Ia., Ionin V.P.
Application of new technologies in resection of the liver
State educational institution of higher education of the federal Agency for Healthcare and Social Development “Chelyabinsk State Medical Academy”, Chelyabinsk, Russia
Against the background of operations using expensive equipment, the results of liver resection by the apparatus-plastic method produce favorable impression. Positive results are obtained due to the simplicity of performing resections and reliable sealing of the wound surface by the laser "welding". Favorable course of the postoperative period depended on the minimal volume of the intraoperative blood loss, the absence of exude complications in the postoperative period.
Вестник хирургии им. И.И. Грекова/”Vestnik Khirurgii Imeni I.I. Grekova”, 2010, том 169, №5, с. 88-90
